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Zoledronic acid, also known as zoledronate and sold under the brand name Zometa among others, by Novartis among others, is a medication used to treat a number of bone diseases. These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone and Duchenne muscular dystrophy (DMD). It is given by injection into a vein.
Read the full article on WikipediaAdjuvant management of breast cancer Clinical criteria: Population criteria: Patient must be post-menopausal. Treatment criteria: Patient must not be undergoing PBS-subsidised treatment with this drug for this indication for more than 36 months.
Bone metastases Clinical criteria: The condition must be due to breast cancer.
Hypercalcaemia of malignancy Clinical criteria: Patient must have a malignancy refractory to anti-neoplastic therapy.
Corticosteroid-induced osteoporosis Clinical criteria: Patient must currently be on long-term (at least 3 months), high-dose (at least 7.5 mg per day prednisolone or equivalent) corticosteroid therapy, AND Patient must have a Bone Mineral Density (BMD) T-score of -1.5 or less, AND Patient must not receive concomitant treatment with any other PBS-subsidised anti-resorptive agent for this condition, AND Patient must not receive more than one PBS-subsidised treatment per year. The duration and dose of corticosteroid therapy together with the date, site (femoral neck or lumbar spine) and score of the qualifying BMD measurement must be documented in the patient's medical records when treatment is initiated.
Osteoporosis Clinical criteria: Population criteria: Patient must be aged 70 years or older. Patient must have a Bone Mineral Density (BMD) T-score of -3.0 or less, AND Patient must not receive concomitant treatment with any other PBS-subsidised anti-resorptive agent for this condition, AND Patient must not receive more than one PBS-subsidised treatment per year. The date, site (femoral neck or lumbar spine) and score of the qualifying BMD measurement must be documented in the patient's medical records when treatment is initiated.
Established osteoporosis Clinical criteria: Patient must have fracture due to minimal trauma, AND Patient must not receive concomitant treatment with any other PBS-subsidised anti-resorptive agent for this condition, AND Patient must not receive more than one PBS-subsidised treatment per year. The fracture must have been demonstrated radiologically and the year of plain x-ray or computed tomography (CT) scan or magnetic resonance imaging (MRI) scan must be documented in the patient's medical records when treatment is initiated. A vertebral fracture is defined as a 20% or greater reduction in height of the anterior or mid portion of a vertebral body relative to the posterior height of that body, or, a 20% or greater reduction in any of these heights compared to the vertebral body above or below the affected vertebral body.
Symptomatic Paget disease of bone Clinical criteria: Only 1 treatment each year per patient will be PBS-subsidised
“146 hours”
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