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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Warfarin is thought to interfere with clotting factor synthesis by inhibition of the C1 subunit of the vitamin K epoxide reductase (VKORC1) enzyme complex, thereby reducing the regeneration of vitamin K1 epoxide.”
“The terminal half-life of warfarin after a single dose is approximately one week; however, the effective half- life ranges from 20 to 60 hours with a mean of about 40 hours.”
“Warfarin is stereoselectively metabolised by hepatic microsomal enzymes (cytochrome P450) to inactive hydroxylated metabolites (predominant route) and by reductases to reduced metabolites (warfarin alcohols).”