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Vemurafenib (INN), sold under the brand name Zelboraf, is a medication used for the treatment of late-stage melanoma. It is an inhibitor of the B-Raf enzyme and was developed by Plexxikon.
Read the full article on WikipediaUnresectable Stage III or Stage IV malignant melanoma Clinical criteria: Treatment Phase: Initial treatment The condition must be positive for a BRAF V600 mutation, AND The condition must not have been treated previously with PBS-subsidised BRAF inhibitor therapy for unresectable Stage III or Stage IV disease; OR Patient must have developed intolerance to other BRAF inhibitors of a severity necessitating permanent treatment withdrawal, AND Patient must not have experienced disease progression whilst on adjuvant BRAF inhibitor treatment or disease recurrence within 6 months of completion of adjuvant BRAF inhibitor with MEK inhibitor treatment if previously treated for resected Stage IIIB, IIIC or IIID melanoma, AND Patient must have a WHO performance status of 2 or less.
“Vemurafenib causes programmed cell death in melanoma cell lines. Vemurafenib interrupts the B-Raf/MEK step on the B-Raf/MEK/ERK pathway − if the B-Raf has the common V600E mutation.”
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