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Valaciclovir, also spelled valacyclovir, is an antiviral medication used to treat outbreaks of herpes simplex or herpes zoster (shingles). It is also used to prevent cytomegalovirus following a kidney transplant in high risk cases. It is taken by mouth.
Read the full article on WikipediaRecurrent moderate to severe genital herpes Clinical criteria: Treatment Phase: Suppressive therapy Microbiological confirmation of diagnosis [viral culture, antigen detection or nucleic acid amplification by polymerase chain reaction (PCR)] is desirable but need not delay treatment.
Cytomegalovirus infection and disease Clinical criteria: Treatment Phase: Prophylaxis Patient must have undergone a renal transplant, AND Patient must be at risk of cytomegalovirus disease.
Herpes zoster Clinical criteria: The treatment must be administered within 72 hours of the onset of the rash.
Initial moderate to severe genital herpes Clinical criteria: Microbiological confirmation of diagnosis [viral culture, antigen detection or nucleic acid amplification by polymerase chain reaction (PCR)] is desirable but need not delay treatment.
“Aciclo-GTP, the active triphosphate metabolite of aciclovir, is a very potent inhibitor of viral DNA replication. Aciclo-GTP competitively inhibits and inactivates the viral DNA polymerase. Its monophosphate form also incorporates into the viral DNA, resulting in chain termination. It has also been shown that the viral enzymes cannot remove aciclo-GMP from the chain, which results in inhibition of further activity of DNA polymerase. Aciclo-GTP is fairly rapidly metabolized within the cell, possibly by cellular phosphatases.”
“<30 minutes (valaciclovir);2.5–3.6 hours (aciclovir)”
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