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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Vadadustat is an inhibitor of hypoxia-inducible factor prolyl-hydroxylase (HIF-PH), a group of enzymes that degrade a subunit of hypoxia-inducible factor (HIF) in the presence of oxygen under normal physiological conditions.”
“The half-life of vadadustat in DD-CKD patients was 9.2 hours.”
“Vadadustat was considered to be an inducer of CYP2B6 in in vitro experiments. However, this interaction has not been examined in vivo.”