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Triptorelin, sold under the brand name Decapeptyl among others, is a medication that acts as an agonist analog of gonadotropin-releasing hormone, repressing expression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It was patented in 1975 and approved for medical use in 1986. Triptorelin is a therapeutic alternative on the World Health Organization's List of Essential Medicines.
Read the full article on WikipediaAssisted Reproductive Technology Clinical criteria: The treatment must be for prevention of premature luteinisation and ovulation, AND Patient must be undergoing controlled ovarian stimulation, AND Patient must be receiving medical services as described in items 13200, 13201, 13202 or 13203 of the Medicare Benefits Schedule.
Locally advanced (stage C) or metastatic (stage D) carcinoma of the prostate Clinical criteria: Treatment criteria: Must be treated by a medical practitioner; OR Must be treated by a nurse practitioner where both of the following are occurring: (i) patient care is being shared with a medical practitioner, (ii) the prescription continues existing therapy with this medicine.
Central precocious puberty Clinical criteria: Treatment Phase: Initial treatment Treatment criteria: Must be treated by a paediatric endocrinologist; OR Must be treated by an endocrinologist specialising in paediatrics. Population criteria: Patient must be of an age that is prior to their 12th birthday if female; OR Patient must be of an age that is prior to their 13th birthday if male, AND Patient must have had onset of signs/symptoms of central precocious puberty prior to their 9th birthday if female; OR Patient must have had onset of signs/symptoms of central precocious puberty prior to their 10th birthday if male.
“The elimination half-life for patients with hepatic impairment was similar to that of patients with renal impairment (geometric mean t(1/2, z): 6.6 h, 7.7 h and 7.6 h for Groups II, III and IV, respectively), but significantly longer than in healthy volunteers (2.8 h for Group I) Triptorelin is a gonadotropin-releasing hormone (GnRH) analogue with enhanced affinity for GnRH receptors and a prolonged half-life due to its resistance to enzymatic degradation.”
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