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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Tiotropium is a long-acting, specific antimuscarinic (anticholinergic) agent.”
“The effective half-life of tiotropium ranges between 27 to 45 h following inhalation by patients with COPD.”
“In vitro studies in human liver microsomes revealed that the enzymatic pathway, relevant for only a small amount of tiotropium metabolism, can be inhibited by cytochrome P450 (CYP) 2D6 inhibitor quinidine and CYP 3A4 inhibitors ketoconazole and gestodene. Tiotropium, even in supra-therapeutic concentrations, does not inhibit CYP 1A1, 1A2, 2B6, 2C9, 2C19, 2D6, 2E1 or 3A in human liver microsomes.”
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