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Malignant neoplasia (late stage) Clinical criteria: Treatment criteria: Must be treated by a health practitioner who is any of: (i) a medical practitioner, (ii) an authorised PBS prescriber who is not a medical practitioner, but who is: (a) sharing care of the patient with at least one medical practitioner; (b) intending to share care of the patient with a medical practitioner.
Insomnia Clinical criteria: Patient must be receiving this drug for the management of insomnia, AND Patient must be receiving long-term nursing care on account of age, infirmity or other condition in a hospital, nursing home or residential facility, AND Patient must have demonstrated, within the past 6 months, benzodiazepine dependence by an unsuccessful attempt at gradual withdrawal.
For prescribing by certain health practitioners Clinical criteria: Treatment criteria: Must be treated by a health practitioner who is any of: (i) a medical practitioner, (ii) a nurse practitioner, (iii) an endorsed midwife where patient care is being shared with a medical practitioner.
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“The exact mechanism of action of benzodiazepines has not yet been elucidated; however, benzodiazepines appear to work through several mechanisms.”
“Pharmacokinetic studies have shown that APO-TEMAZEPAM is well absorbed and has a relatively short elimination half-life of approximately 10 hours (range 5 - 15 hours).”
“The cytochrome P450 system has not been shown to be involved in the disposition of APO-TEMAZEPAM and, unlike many benzodiazepines, pharmacokinetic interactions involving the P450 system have not been observed with APO-TEMAZEPAM.”
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.