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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Teclistamab is a bispecific antibody that targets the CD3 receptor expressed on the surface of T cells and B cell maturation antigen (BCMA), which is expressed on the surface of malignant multiple myeloma B-lineage cells, as well as late-stage B cells and plasma cells.”
“Patients who discontinue teclistamab after the 13th weekly treatment dose are expected to have a 50% reduction from Cmax in teclistamab concentration at a median (5th to 95th percentile) time of 15 (7 to 33) days after Tmax and a 97% reduction from Cmax in teclistamab concentration at a median time of 69 (32 to 163) days after Tmax.”
Working under the parallel aged-care framework? Aged-care equivalent →
“The initial release of cytokines associated with the start of TECVAYLI treatment could suppress CYP450 enzymes.”