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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“The mechanism of action of somapacitan is either directly via the GH-receptor and/or indirectly via IGF-I produced in tissues throughout the body, but predominantly by the liver.”
“Data from an interaction study performed in growth hormone deficient adults suggests that growth hormone administration may increase the clearance of compounds known to be metabolised by cytochrome P450 isoenzymes. The clearance of compounds metabolised by cytochrome P450 (e.g. sex steroids, corticosteroids, anticonvulsants and ciclosporine) may be especially increased resulting in lower plasma levels of these compounds.”
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