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“This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl- coenzyme A (HMG-CoA) reductase, an enzyme which catalyses an early and rate-limiting step in the biosynthesis of cholesterol.”
“2 hours for simvastatin and 1.9 hours for simvastatin acid”
“Simvastatin and other HMG-CoA reductase inhibitors are metabolised by CYP 3A4 (see Section 4.4 SPECIAL WARNINGS AND PRECAUTIONS FOR USE - Myopathy/Rhabdomyolysis).”
Working under the parallel aged-care framework? Aged-care equivalent →
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.