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Sepiapterin, sold under the brand name Sephience, is a medication used for the treatment of hyperphenylalaninemia. Sepiapterin is a phenylalanine hydroxylase activator. It is also metabolite that is naturally synthesized in the human body.
Read the full article on Wikipedia“Sepiapterin is a metabolite that is naturally synthesized in the human body. Synthetic sepiapterin also functions as a prodrug that serves as a precursor to tetrahydrobiopterin (BH4). The therapeutic effect of sepiapterin results from its conversion to BH4, which functions as a cofactor for phenylalanine hydroxylase (PAH). This enzymatic activity enables patients with phenylketonuria (PKU) to better metabolize phenylalanine, thereby reducing its neurotoxic concentration in the blood.”
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