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“Rosuvastatin is a fully synthetic competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol.”
“The half-life is 19 hours and does not increase with increasing dose.”
“In vitro and in vivo data indicate that rosuvastatin clearance is not dependent on metabolism by cytochrome P450 3A4 to a clinically significant extent (see Table 1 for interaction studies with ketoconazole, erythromycin, fluconazole and itraconazole).”
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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.