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Neuropathic pain Clinical criteria: The condition must be refractory to treatment with other drugs.
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“In vitro studies show that pregabalin binds to an auxiliary subunit ( α 2- δ protein) of voltage-gated calcium channels in the central nervous system, potently displacing [ 3 H]-gabapentin.”
“Pregabalin mean elimination half-life is 6.3 hours.”
“Since pregabalin is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans (<2% of a dose recovered in urine as metabolites), does not inhibit drug metabolism in vitro, and is not bound to plasma proteins, pregabalin is unlikely to produce, or be subject to, pharmacokinetic interactions.”
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.