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“Animal studies suggest that the vasodilator effect of prazosin is related to blockade of post-synaptic alpha adrenoreceptors.”
“Following oral administration to normal volunteers and hypertensive patients, plasma concentrations reach a peak in 1 to 2 hours, with a plasma half-life of 2 to 3 hours. Pharmacokinetic data in a limited number of patients with congestive heart failure, most of whom showed evidence of hepatic congestion, indicate that peak plasma concentrations are reached in 2.5 hours and plasma half-life is approximately 7 hours.”
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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.