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Phenelzine, sold under the brand name Nardil among others, is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine family which is primarily used as an antidepressant and anxiolytic to treat depression and anxiety. Along with tranylcypromine and isocarboxazid, phenelzine is one of the few non-selective and irreversible MAOIs still in widespread clinical use.
Read the full article on WikipediaDepression Clinical criteria: The treatment must be for when all other anti-depressant therapy has failed; OR The treatment must be for when all other anti-depressant therapy is inappropriate.
“Phenelzine is a non-selective and irreversible inhibitor of the enzyme monoamine oxidase. It inhibits both of the respective isoforms of monoamine oxidase (MAO), MAO-A and MAO-B, and does so almost equally, with a slight preference for the former. By inhibiting MAO, phenelzine prevents the breakdown of the monoamine neurotransmitters serotonin, melatonin, norepinephrine, epinephrine, and dopamine, as well as trace amine neuromodulators such as phenethylamine, tyramine, octopamine, and tryptamine. Consequently, the amount of these neurochemicals in the synaptic cleft increases, ultimately affecting neurotransmission. This action is thought to be the primary mediator in phenelzine's therapeutic benefits.”
“11.6 hours”
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