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“Pethidine is a synthetic opioid with analgesic and sedative properties, its actions qualitatively similar to those of morphine.”
“Pethidine has an average plasma elimination half-life of approximately 3.2 ± 0.8 hours.”
“The concomitant use of pethidine and CYP3A4 or CYP2B6 inhibitors such as macrolide antibiotics (e.g. erythromycin), azole-antifungal agents (e.g. ketoconazole), and protease inhibitors (e.g. ritonavir), can increase the plasma concentration of pethidine, resulting in increased or prolonged opioid effects.”