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Pazopanib, sold under the brand name Votrient, is an anti-cancer medication marketed worldwide by Novartis. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. It has been approved for renal cell carcinoma and soft tissue sarcoma by numerous regulatory administrations worldwide.
Read the full article on WikipediaAdvanced (unresectable and/or metastatic) soft tissue sarcoma Clinical criteria: Treatment Phase: Initial treatment Patient must have a WHO performance status of 2 or less, AND Patient must have received prior chemotherapy treatment including an anthracycline, AND Patient must not have received prior treatment with an angiogenesis inhibitor, AND The treatment must be the sole PBS-subsidised therapy for this condition. Patient must not have any of the following conditions: adipocytic soft tissue sarcoma; gastrointestinal stromal tumour (GIST); rhabdomyosarcoma other than alveolar or pleomorphic; chondrosarcoma; osteosarcoma; Ewings tumour/primitive neuroectodermal tumour; dermofibromatosis sarcoma protuberans; inflammatory myofibroblastic sarcoma; malignant mesothelioma; mixed mesodermal tumour of the uterus.
Stage IV clear cell variant renal cell carcinoma (RCC) Clinical criteria: Treatment Phase: Continuing treatment beyond 3 months Patient must have received an initial authority prescription for this drug for this condition, AND Patient must have stable or responding disease according to the Response Evaluation Criteria In Solid Tumours (RECIST), AND The treatment must be the sole PBS-subsidised tyrosine kinase inhibitor therapy for this condition. A patient who has progressive disease when treated with this drug is no longer eligible for PBS-subsidised treatment with this drug. PBS-subsidy does not apply to a patient who has progressive disease whilst on, or, who has recurrent disease following treatment with any of: (i) cabozantinib, (ii) pazopanib, (iii) sunitinib.
“Pazopanib is a multiple kinase inhibitor that limits tumor growth by targeting angiogenesis via inhibition of enzymes including vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), c-KIT and FGFR.”
“30.9±4 hours”
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