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Major depressive disorders Clinical criteria: The condition must be stable for the prescriber to consider the listed maximum quantity of this medicine suitable for this patient.
Obsessive-compulsive disorder Clinical criteria: The condition must be stable for the prescriber to consider the listed maximum quantity of this medicine suitable for this patient.
“Paroxetine is a potent and selective inhibitor of 5-hydroxytryptamine (5-HT, serotonin) uptake and its antidepressant action and efficacy in the treatment of obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder/social phobia, General Anxiety Disorder and Post-traumatic Stress Disorder are thought to be related to its specific inhibition of 5-HT uptake in brain neurones.”
“The elimination half-life is variable but is generally about one day. However, because of the reduction in plasma clearance which occurs on multiple dosing (non-linear kinetics: see Absorption), 7-14 days are required for the achievement of steady state.”
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Panic disorder Clinical criteria: The condition must be stable for the prescriber to consider the listed maximum quantity of this medicine suitable for this patient.
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“As with other antidepressants, including other SSRIs, paroxetine inhibits the specific hepatic cytochrome P450 enzyme 2D6 (CYP2D6). This may lead to enhanced plasma levels of those co-administered drugs, which are metabolised to a significant extent by this isoenzyme, although the clinical significance of the interaction will depend on the therapeutic window of the affected drug.”