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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“The mechanism of action of valdecoxib is by inhibition of cyclooxygenase-2 (COX-2)-mediated prostaglandin synthesis.”
“The elimination half-life (T1/2) of valdecoxib after IV or IM dosing of parecoxib (as sodium) is about 8 hours.”
“In vitro studies with human hepatic microsomal systems showed no significant inhibitory effects on CYP3A4, 2D6, 2E1, and 1A2 isoforms by parecoxib and valdecoxib. Weak inhibitory activity was found for 2C9 and 2C19 isozymes.”
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