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Nicotine is an alkaloid found primarily in plants of the nightshade family, notably in tobacco; it is also synthesized. Nicotine is used recreationally for its stimulant and anxiolytic effects. In tobacco leaves, nicotine constitutes about 0.6–3.0% of the dry weight, and smaller, trace quantities occur in other Solanaceae crops such as tomatoes, potatoes, and eggplants. In pure form, nicotine is a colorless to yellowish, oily liquid that readily penetrates biological membranes and acts as a potent neurotoxin in insects, where it serves as an antiherbivore toxin. Historically, it was widely used as an insecticide, and its structure provided the basis for synthetic neonicotinoid pesticides.
Read the full article on WikipediaNicotine dependence Clinical criteria: The treatment must be as an aid to achieving abstinence from smoking, AND The treatment must not be a PBS-benefit with other non-nicotine drugs that are PBS indicated for smoking cessation, AND Patient must have indicated they are ready to cease smoking, AND Patient must not receive more than 2 x 12-week PBS-subsidised treatment courses per 12 month period. Treatment criteria: Patient must be undergoing concurrent counselling for smoking cessation through a comprehensive support and counselling program or is about to enter such a program at the time PBS-subsidised treatment is initiated. Details of the support and counselling program must be documented in the patient's medical records at the time treatment is initiated.
“Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist. Such antagonism results in mild analgesia.”
“1–2 hours; 16–19 hours cotinine (range is 10–27 hours)”
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