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“Specific bactericidal activity against important obligate anaerobes.”
“The biological half-life of oral and intravenous metronidazole has been determined as 6 to 7 and 7.3 hours respectively.”
“The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital (phenobarbitone), may accelerate the elimination of metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported. The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of metronidazole.”
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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.