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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Metoprolol, the active substance of METOPROLOL-WGR, is a relatively cardioselective beta-blocker, i.e. it acts on beta1-receptors mainly located in the heart at lower doses than those needed to influence the beta2-receptors mainly located in the bronchi and peripheral vessels.”
“The elimination half-life of metoprolol is between 3 and 5 hours.”
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“The oxidative metabolism of metoprolol is under genetic control with a major contribution of the polymorphic cytochrome P450 isoform 2D6 (CYP2D6).”