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Severe active rheumatoid arthritis Clinical criteria: Patient must be unsuitable for administration of an oral form of methotrexate for this condition.
Severe psoriasis Clinical criteria: The condition must not have adequately responded to topical treatment, AND Patient must be unsuitable for administration of an oral form of methotrexate for this condition.
“Methotrexate has as its principal mechanism of action the competitive inhibition of the enzyme folic acid reductase.”
“Elimination is triphasic. The first phase probably describes distribution into organs; the second, renal excretion; and the third, passing of methotrexate into the enterohepatic circulation.”
Working under the parallel aged-care framework? Aged-care equivalent →
Severe active juvenile idiopathic arthritis Clinical criteria: Patient must be unsuitable for administration of an oral form of methotrexate for this condition.
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.