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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Melphalan is a bifunctional alkylating agent. Formation of carbonium intermediates from each of the two bis- 2-chloroethyl groups enables alkylation through covalent binding with the 7- nitrogen of guanine on DNA, cross-linking two DNA strands and thereby preventing cell replication.”
“Following injection, drug plasma concentrations declined rapidly in a biexponential manner with distribution phase and terminal elimination phase half-lives of approximately 10 and 75 minutes, respectively.”
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