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Crusted (Norwegian) scabies Clinical criteria: The condition must be established by clinical and/or parasitological examination, AND Patient must be undergoing topical therapy for this condition; OR Patient must have a contraindication to topical treatment. Population criteria: Patient must weigh 15 kg or over, AND Patient must be 5 years of age or older.
Human sarcoptic scabies Clinical criteria: The condition must be established by clinical and/or parasitological examination, AND Patient must have completed and failed sequential treatment with topical permethrin and benzyl benzoate and finished the most recent course of topical therapy at least 4 weeks prior to initiating oral therapy; OR Patient must have a contraindication to topical treatment. Population criteria: Patient must weigh 15 kg or over, AND Patient must be 5 years of age or older.
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Avermectin has been reported to exert anti-inflammatory effects by inhibiting lipopolysaccharide-induced production of inflammatory cytokines.”
“The apparent terminal half-life averaged 6 days (mean: 145 hours, range 92-238 hours) in subjects receiving a once daily topical application of the medicinal product for 28 days, in the maximal use clinical pharmacokinetic study.”
Working under the parallel aged-care framework? Aged-care equivalent →
“In vitro studies using human hepatic microsomes and recombinant CYP450 enzymes have shown that ivermectin is primarily metabolized by CYP3A4. In vitro studies show that ivermectin does not inhibit the CYP450 isoenzymes 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 3A4, 4A11 or 2E1. Ivermectin does not induce CYP450 enzyme expression (1A2, 2B6, 2C9 or 3A4) in cultured human hepatocytes.”