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Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.
Read the full article on WikipediaChronic arthropathies (including osteoarthritis) Clinical criteria: The condition must have an inflammatory component.
Bone pain Clinical criteria: The condition must be due to malignant disease.
Severe pain Clinical criteria: Patient must be receiving palliative care.
“Indometacin, a non-steroidal anti-inflammatory drug (NSAID), has similar mode of action when compared to other drugs in this group. It is a nonselective inhibitor of cyclooxygenase (COX) 1 and 2, the enzymes that participate in prostaglandin synthesis from arachidonic acid. Prostaglandins are hormone-like molecules normally found in the body, where they have a wide variety of effects, some of which lead to pain, fever, and inflammation. By inhibiting the synthesis of prostaglandins, indometacin can reduce pain, fever, and inflammation. Mechanism of action of indomethacin, along with several other NSAIDs that inhibit COX, was described in 1971.”
“2.6-11.2 hours (adults), 12-28 hours (infants)”
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