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Imiquimod, sold under the brand name Aldara among others, is a medication that acts as an immune response modifier that is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Read the full article on WikipediaSolar keratosis Clinical criteria: Patient must require topical drug therapy on the face and scalp as field treatment for clinically visible and subclinical lesions where other standard treatments are inappropriate.
Superficial basal cell carcinoma Clinical criteria: The condition must be previously untreated, AND The condition must be confirmed by biopsy, AND Patient must have normal immune function, AND The condition must not be suitable for treatment with surgical excision; OR The condition must not be suitable for treatment with cryotherapy; OR The condition must not be suitable for treatment with curettage with diathermy, AND Patient must require topical drug therapy. The date of the pathology report and name of the Approved Pathology Authority must be provided at the time of application.
“Imiquimod yields profound antitumoral activity by acting on several immunological levels synergistically. Imiquimod stimulates the innate immune system by activating toll-like receptor 7 (TLR7), commonly involved in pathogen recognition. Cells activated by imiquimod via TLR-7 secrete cytokines (primarily interferon-α (IFN-α), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)). There is evidence that imiquimod, when applied to skin, can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system. Other cell types activated by imiquimod include natural killer cells, macrophages and B-lymphocytes.”
“30 hours (topical dose), 2 hours (subcutaneous dose)”
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