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Chronic arthropathies (including osteoarthritis) Clinical criteria: The condition must have an inflammatory component.
Bone pain Clinical criteria: The condition must be due to malignant disease.
“Its mechanism of action is known to be through peripheral inhibition of cyclooxygenases and subsequent prostaglandin synthetase inhibition.”
“The elimination half-life in healthy individuals and those with liver and kidney diseases is 1.8 - 3.5 hours.”
“Concomitant administration of ibuprofen with CYP2C9 inhibitors may increase the exposure to ibuprofen (CYP2C9 substrate).”
Severe pain Clinical criteria: Patient must be receiving palliative care.
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.