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Severe primary axillary hyperhidrosis Clinical criteria: Patient must have previously failed topical aluminium chloride hexahydrate after one to two months of treatment; OR Patient must be intolerant to topical aluminium chloride treatment, AND The treatment must be the sole PBS-subsidised therapy for this condition.
“Glycopyrronium is a competitive antagonist of the muscarinic acetylcholine receptors.”
“Pharmacokinetic studies in normal volunteers given a single intravenous infusion of 0.4 mg glycopyrronium bromide (glycopyrrolate) showed that the drug undergoes a rapid distribution/elimination phase (t1/2= 5 min) followed by a more prolonged termination elimination phase (t1/2 = 1.7 hr).”
Working under the parallel aged-care framework? Aged-care equivalent →
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“CYP2D6 was found to be the predominant CYP isoform involved in the metabolism of glycopyrronium.”