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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“The contraceptive effect of COCs is based on the interaction of various factors. The primary mechanisms are inhibition of ovulation (by suppression of gonadotropins) and changes in cervical secretion (blocking the entry of sperm into the uterus).”
“Ethinylestradiol serum levels decrease in two phases, the terminal disposition phase is characterised by a half-life of approximately 24 hours.”
“Additionally, based on in vitro and in vivo studies, CYP3A4 is the main enzyme involved in the oxidative metabolism of levonorgestrel.”