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“Non-clinical studies have shown that desvenlafaxine is a selective serotonin and noradrenaline reuptake inhibitor (SNRI).”
“The mean terminal half-life ( t 1/2 ) is approximately 11 hours. With once-daily dosing, steady-state plasma concentrations are achieved within approximately 4-5 days.”
“In vitro studies showed that CYP3A4 is the predominant cytochrome P450 isozyme mediating the oxidative metabolism ( N - demethylation) of desvenlafaxine.”
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.