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“In isolated nerve-muscle preparations, DANTRIUM has been shown to produce relaxation of the contractile state of the skeletal muscle by an effect beyond the myoneural junction and directly on the muscle itself. In these preparations DANTRIUM uncouples the excitation and contraction of the skeletal muscle, probably by interfering with the release of calcium ions from the sarcoplasmic reticulum.”
“The mean biological half-life of DANTRIUM in adults is 8.7 hours after a 100 mg dose.”
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“Since DANTRIUM is probably metabolised by hepatic microsomal enzymes, enhancement of its metabolism by other drugs is possible. However, neither phenobarbital nor diazepam appears to affect DANTRIUM metabolism.”