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Dacarbazine, also known as imidazole carboxamide and previously sold under the brand name DTIC-Dome, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. For Hodgkin's lymphoma, it is often used together with vinblastine, bleomycin, and doxorubicin. It is given by injection into a vein.
Read the full article on Wikipedia“Dacarbazine is converted to 5-aminoimidazole-4- carboxamide (AIC) by liver microsomal enzymes. The precursors to AIC is 5-(3-methyltriazene-1-yl)imidazole-4-carboxamide (MTIC), which is an alkylating compound. The tautomer of MTIC causes methylation, modification and cross linking of DNA, thus inhibiting DNA, RNA and protein synthesis and producing AIC as a product.”
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