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For prescribing by certain health practitioners Clinical criteria: Treatment criteria: Must be treated by a medical practitioner; OR Must be treated by a nurse practitioner where both of the following are occurring: (i) patient care is being shared with a medical practitioner, (ii) the prescription continues existing therapy with this medicine.
“Cyclophosphamide is converted by a series of reactions in the liver to its active form which interferes with the growth of susceptible neoplasms and to a certain extent, with normal tissue regeneration.”
“Intravenously administered cyclophosphamide is reported to have a serum half- life of about 4 hours, however the drug and/or its metabolites may be detected in plasma for up to 72 hours.”
Working under the parallel aged-care framework? Aged-care equivalent →
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Barbiturates and other drugs which induce liver microsomal enzymes, such as phenytoin, benzodiazepines and chloral hydrate may result in an increased pharmacological effect and increased toxicity of cyclophosphamide because of increased conversion of the drug to active (alkylating) metabolites.”