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Severe pain Clinical criteria: The treatment must be for short term therapy of acute severe pain, AND Patient must have had or would have inadequate pain management with maximum tolerated doses of non-opioid analgesics; OR Patient must be unable to use non-opioid analgesics due to contraindications or intolerance.
“Codeine causes suppression of the cough reflex by a direct effect on the cough centre in the medulla of the brain and appears to exert a drying effect on the respiratory tract mucosa and to increase viscosity of bronchial secretions.”
“2.5–3 hours”
“Patients who metabolise drugs poorly via CYP2D6 are likely to obtain reduced benefit from codeine due to reduced formation of the active metabolite.”
Working under the parallel aged-care framework? Aged-care equivalent →
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.