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“Evidence suggests that the observed decreased turnover rate of these various neurotransmitters can be explained in a unified way by a primary action of benzodiazepines on the GABA system through a facilitation of GABA-ergic neurotransmission.”
“In one study, after a single dose of 20 mg, the following half-lives were observed: young men 17 hours; young women 31 hours; elderly men 48 hours; elderly women 49 hours.”
“Clobazam is demethylated by CYP 3A4, and to a lesser extent by 2C19 and 2B6 to formthe active metabolite N-desmethyl-clobazam (N-CLB), which itself is further metabolised by CYP 2C19 into 4'-hydroxy-N-desmethyl-clobazam.”