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“Evidence suggests that the observed decreased turnover rate of these various neurotransmitters can be explained in a unified way by a primary action of benzodiazepines on the GABA system through a facilitation of GABA-ergic neurotransmission.”
“In man, the plasma elimination phase of unchanged clobazam varies with age and sex. In one study, after a single dose of 20 mg, the following half-lives were observed: young men 17 hours; young women 31 hours; elderly men 48 hours; elderly women 49 hours. The plasma beta elimination phase of the major plasma metabolite, N- desmethyl-clobazam is considerably longer and is about 2 to 3 days for young men and women and 3 to 5 days for elderly men and women.”
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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Clobazam is demethylated by CYP 3A4, and to a lesser extent by 2C19 and 2B6 to formthe active metabolite N-desmethyl-clobazam (N-CLB), which itself is further metabolised by CYP 2C19 into 4'-hydroxy-N-desmethyl-clobazam. Clobazam is a weak CYP2D6 inhibitor.”