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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Agomelatine is a melatonin receptor (MT 1 and MT 2 ) agonist and 5-HT 2C receptor antagonist.”
“Elimination is rapid. The mean plasma half-life is between one and two hours.”
“Following oral administration, agomelatine is rapidly oxidized mainly by the hepatic cytochromes CYP1A2 (90%) and CYP2C9/CYP2C19 (10%).”