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Respiratory tract infection Clinical criteria: The condition must be proven or suspected to be caused by Pseudomonas aeruginosa, AND Patient must be severely immunocompromised.
Bacterial gastroenteritis Clinical criteria: Patient must be severely immunocompromised.
“The bactericidal action of ciprofloxacin appears to result from interference with the enzyme, DNA gyrase.”
“During the first hour after completion of infusion, serum concentration decreases to approximately 30% of the peak value, but thereafter serum concentrations decline with a half life of approximately four hours.”
Working under the parallel aged-care framework? Aged-care equivalent →
Infection Clinical criteria: The condition must be proven to be due to Pseudomonas aeruginosa resistant to all other oral antimicrobials; OR The condition must be proven to be due to other gram-negative bacteria resistant to all other oral antimicrobials.
Bone or joint infection Clinical criteria: The condition must be suspected or proven to be caused by gram-negative bacteria resistant to all other appropriate antimicrobials; OR The condition must be suspected or proven to be caused by gram-positive bacteria resistant to all other appropriate antimicrobials.
Epididymo-orchitis Clinical criteria: The condition must be suspected or proven to be caused by gram-negative bacteria resistant to all other appropriate antimicrobials; OR The condition must be suspected or proven to be caused by gram-positive bacteria resistant to all other appropriate antimicrobials.
Prostatitis Clinical criteria: The condition must be suspected or proven to be caused by gram-negative bacteria resistant to all other appropriate antimicrobials; OR The condition must be suspected or proven to be caused by gram-positive bacteria resistant to all other appropriate antimicrobials.
Perichondritis of the pinna Clinical criteria: The condition must be suspected or proven to be caused by gram-negative bacteria resistant to all other appropriate antimicrobials; OR The condition must be suspected or proven to be caused by gram-positive bacteria resistant to all other appropriate antimicrobials.
Bacterial keratitis Clinical criteria: Treatment criteria: Must be treated by an ophthalmologist or in consultation with an ophthalmologist.
Chronic suppurative otitis media Clinical criteria: Population criteria: Patient must be an Aboriginal or a Torres Strait Islander person, AND Patient must be aged 1 month or older.
Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Ciprofloxacin is known to be a moderate inhibitor of the CYP450 1A2 enzymes.”