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Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen among others. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication. It binds to the N7 nitrogen on the DNA base guanine. As the chemical is a blister agent, its use is strongly restricted within the Chemical Weapons Convention where it is classified as a Schedule 1 substance.
Read the full article on WikipediaMycosis fungoides cutaneous T-cell lymphoma Clinical criteria: Treatment Phase: Initial treatment The condition must be any of: (i) Stage IA, (ii) IIA, (iii) IB mycosis fungoides cutaneous T-cell lymphoma, AND The condition must have been confirmed through a diagnostic lesion biopsy from an Approved Pathology Authority, AND The condition must cover either of which: (i) no more than 10% of the patient's body surface area, (ii) no more than 25% of the patient's body surface area, AND Patient must be treated by at least one of the following prescriber types (i) dermatologist, (ii) haematologist, AND The treatment must be approved for 1 unit if the condition is no more than 10% of the patient's body surface area to provide 4 weeks of treatment per script; OR The treatment must be approved for 2 units if the condition is no more than 25% of the patient's body surface area to provide 4 weeks of treatment per script. Population criteria: Patient must be at least 18 years of age. Confirmation of eligibility for treatment with diagnostic reports must be documented in the patient's medical records.
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