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Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. Cefalexin is a β-lactam antibiotic within the class of first-generation cephalosporins. It works similarly to other agents within this class, including intravenous cefazolin, but can be taken by mouth.
Read the full article on WikipediaOsteomyelitis Clinical criteria: Treatment criteria: Must be treated by a medical practitioner; OR Must be treated by a nurse practitioner where this prescription is to continue existing therapy with this medicine.
Infection Clinical criteria: Patient must have a pin-site infection; OR Patient must have an infection following cardiac device insertion; OR Patient must have acute otitis externa; OR Patient must have streptococcal pharyngitis or tonsillitis; OR Patient must have mastitis; OR Patient must have periorbital (preseptal) cellulitis; OR Patient must have acute rheumatic fever; OR Patient must have a diabetic foot infection; OR Patient must have a widespread infection of dermatitis; OR Patient must require treatment for prophylaxis for invasive group A streptococcal (iGAS) infection; OR Patient must have impetigo; OR Patient must have pyelonephritis; OR Patient must have a condition requiring prolonged oral antibiotic therapy. Midwives may prescribe under this item for the treatment of mastitis only.
“Cefalexin is a β-lactam antibiotic of the cephalosporin family. It is bactericidal and acts by inhibiting synthesis of the peptidoglycan layer of the bacterial cell wall. As cefalexin closely resembles d-alanyl-d-alanine, an amino acid ending on the peptidoglycan layer of the cell wall, it can irreversibly bind to the active site of PBP, which is essential for the synthesis of the cell wall. It is most active against gram-positive cocci, and has moderate activity against some gram-negative bacilli. However, some bacterial cells have the enzyme β-lactamase, which hydrolyzes the β-lactam ring, rendering the drug inactive. This contributes to antibacterial resistance towards cefalexin.”
“0.6–1.2 hours”
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