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Busulfan (Myleran, GlaxoSmithKline; Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug that has been in use since 1959. It is a cell cycle-nonspecific alkylating antineoplastic agent belonging to the alkyl sulfonates class. Its chemical designation is 1,4-butanediol dimethanesulfonate.
Read the full article on Wikipedia“Busulfan is an alkylsulfonate. It is an alkylating agent that forms DNA-DNA interstrand crosslinks between the DNA bases guanine and adenine and between guanine and guanine. This occurs through an SN2 reaction in which the relatively nucleophilic guanine N7 attacks the carbon adjacent to the mesylate leaving group. DNA crosslinking prevents DNA replication. Because the intrastrand DNA crosslinks cannot be repaired by cellular machinery, the cell undergoes apoptosis.”
“2.5 hours”