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Atovaquone, sold under the brand name Mepron, is an naphthoquinone antiprotozoal medication used in the prevention and treatment Pneumocystis jirovecii pneumonia (PCP), and malaria (in combination with proguanil), as well as for treatment of babesiosis (in combination with azithromycin).
Read the full article on WikipediaMild to moderate Pneumocystis carinii pneumonia Clinical criteria: Population criteria: Patient must be an adult, AND Patient must be intolerant of trimethoprim/sulfamethoxazole therapy.
“Atovaquone is a lipophilic analogue of ubiquinone (coenzyme Q10), which serves as electron acceptor of the parasitic inner mitrochondrial membrane cytochrome bc1 complex, which supplies oxidised ubiquinone to the dihydroorotate dehydrogenase, an enzyme that is crucial for parasitic pyrimidine synthesis.”
“2.2–3.2 days”
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