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“Amitriptyline inhibits the membrane pump mechanism responsible for uptake of noradrenaline and serotonin in adrenergic and serotonergic neurons.”
“The mean apparent elimination half-life for amitriptyline was reported by one source to be 22.4 hours; the mean half- life of its active metabolite, nortriptyline was 26 hours.”
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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Concomitant use of tricyclic antidepressants with medicines that can inhibit cytochrome P450 2D6 (e.g. quinidine; cimetidine) and those that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics, e.g. flecainide) may require lower doses than usually prescribed for either the tricyclic antidepressant or the other medicine.”