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Curated subset. The full adverse-effect list is in the TGA Product Information; click any citation above to open it.
“Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.”
“Plasma adefovir concentrations declined in a biexponential manner with a terminal elimination half-life of 7.48 ± 1.65 hours.”
“At concentrations substantially higher (> 4000 fold) than those observed in vivo, adefovir did not inhibit any of the following human CYP 450 isoforms, CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4. Adefovir is not a substrate for these enzymes.”