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Abacavir (ABC), sold under the brand name Ziagen among others, is a medication used to treat HIV/AIDS. Similar to other nucleoside analog reverse-transcriptase inhibitors (NRTIs), abacavir is used together with other HIV medications, and is not recommended by itself. It is taken by mouth as a tablet or solution and may be used in children over the age of three months.
Read the full article on WikipediaHIV infection Clinical criteria: Treatment Phase: Initial Patient must be antiretroviral treatment naive, AND The treatment must be in combination with other antiretroviral agents.
Human immunodeficiency virus (HIV) infection Clinical criteria: Population criteria: Patient must be less than 13.00 years of age. Patient must be unable to take a solid dose form of this drug, AND The treatment must be in combination with other antiretroviral agents.
“Abacavir is a nucleoside reverse transcriptase inhibitor that inhibits viral replication. It is a guanosine analogue that is phosphorylated to carbovir triphosphate (CBV-TP). CBV-TP competes with the viral molecules and is incorporated into the viral DNA. Once CBV-TP is integrated into the viral DNA, transcription and HIV reverse transcriptase is inhibited.”
“1.54 ± 0.63 h”
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